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Health science: selenium and cancer prevention

Add time:2021-12-02    View counts:  

The King of Anti -Cancer in the Trace Element 2003 U.S. Food and Drug Administration (FDA) explicitly stated that "selenium can reduce the risk of cancer" and "selenium can produce anti -cancer effects in the human body, and allow sellers of selenium nutrition products to be as seller as sellers of selenium nutrition products. Selenium cancer suppression effects are identified. Today in the United States, the following legal statements can be made: Declaration 1: Selenium can reduce the risk of cancer. Scientific evidence shows that intake of selenium can reduce the risk of certain cancers. Statement 2: Selenium can be in the selenium in it Anti -cancer effects in the human body. Some Selenium evidence shows that the intake of selenium can produce anticancer degeneration in the human body. In China, selenium anti -cancer and anti -cancer effects have been written into chemical teaching lessons and medical textbooks in colleges and universities. (262 pages of trace elements and health), "Selenium can inhibit the growth of cancer cells and its DNA RNA and protein synthesis, inhibit the transcription of cancer genes, and interfere with the metabolism of carcinogens".亞利圣那大學(xué)癌癥中心Clark教授對(duì)1312例癌癥患者進(jìn)行了長(zhǎng)達(dá)13年大規(guī)模對(duì)照試驗(yàn)，結(jié)果表明，每日補(bǔ)充200微克硒，癌癥的死亡率下降了50%，其中硒對(duì)前列腺癌、 The prevention and control of lung cancer and rectal cancer is very obvious. For those who have not suffered from cancer, the total incidence has dropped by 37%. This pioneering study is called the "selenium -proof milestone" research, which strongly stimulates the research of the international community to pay attention to selenium research And applications. There are obvious regional differences in the distribution of selenium in the environment. Medical geography research shows that the incidence and mortality of tumors are negatively related to the geographical distribution of selenium. The level of selenium in the body of tumor patients is lower than normal people, especially skin cancer and gastrointestinal cancer. Epidemiological surveys show that selenium intake in diet is significantly negatively related to breast cancer, colon cancer and lung cancer. . Studies from foreign scholars suggest that gastrointestinal tract and respiratory tract cancers are most affected by selenium. Shamberger compares the mortality of various tumor in the United States, Canada selenium and low selenium, and found that the stomach, large and small intestines in high selenium areas, large and small intestines, large and small intestines, and intestines, and large and small intestines, The number of deaths caused by kidney, breasts, breasts, uterus, ovarian and other organs is significantly lower than that of low selenium areas. Schraucer investigations in 17 areas in 27 countries have also found that selenium intake and blood selenium levels and reciprocal conercers The incidence of cancer, lung cancer, prostate cancer, ovarian cancer and leukemia is significantly negative. More and more evidence shows that selenium has a certain prevention and treatment effect on human tumors. As early as 1912 and 1915, Dallber, Walker, and Kein After selenium treatment with selenium, Walker and Kein pointed out that the selenium in the skin under the skin will be liquefied and necrotic, and then healing. In 1935, TODD found that the selenium supplementing the selenium in the radiotherapy of patients with metastatic breast cancer played its auxiliary role. Selenine cystine has a therapeutic effect on human acute and chronic leukemia. Jacods found that adding 4mg/L selenium in drinking water can be reduced by more than 50%of colon cancer induced by DMH (1, 2- -2 -in section 2). Finnish Wakhonagan Agricultural University adds selenium to dairy feed -eggine (SE -Methionine) improves selenium content in dairy products to prevent human diseases caused by insufficient selenium. American scholars' research also shows that selenium supplementation can reduce the incidence of colon cancer and breast cancer. Chinese scholars have also conducted in -depth research on the anti -cancer effect of selenium. After more than 10 years of research, Yu Shuyu and others pointed out that sodium selenium can cause the proliferation, differentiation and malignant phenotype of tumor cells. Li Wenguang and Yu Shuyu reported that high -incidence of Qidong liver cancer in Jiangsu Province eat selenium salt to prevent preview of primary liver cancer. By observing 6, the blood and selenium of residents who eat selenium salt increased significantly. The incidence of liver cancer declined year by year, 52.84 people/100,000 in 1984, and in 1990 to 3449 people/100,000. The incidence of liver cancer in the resident group still maintains a high level, and it is prompted to prevent selenium prevent liver cancer. In 1987, Qidong's viral hepatitis was popular, and the incidence of hepatitis in the residents of selenium and salt towns was significantly lower than that of the control group (P <0.01 =. Yu Shuyu was in the high incidence of liver cancer, and it was also a poverty -stricken area. Test: The first experiment was divided into food and selenium salt (including 15ppm Na 2 SEO 3) group and control group (eating ordinary salt) in 130471 cases. The control group decreased an average of 49%(P <0.01 =; the second test subject was 266 carriers of HBSAG, which was randomly divided into selenium serving group (selenium -rich yeast containing 200 μg/d selenium) and control group In 133 cases of the same ordinary yeast), in the 4 -year test, there were no liver cancer in the selenium serving group, and 7 cases of liver cancer occurred in the control group. The difference between the two groups was significant (P <0.05 =; 3849 relatives of the family, randomly divided into 2364 people to the selenium yeast group, 1485 in the control group, for 2 consecutive years, 50%of the incidence of liver cancer (P <0.01 =, and found that the onset of liver cancer in the selenium serving group is found The peak age is delayed for 10 years. Another author reports to add 15 ppm sodium selenium to salt. The results show that the selenium serving the total mortality of cancer and gastric cancer mortality rate is more positive. The 4 -year mortality rate is 4 years of mortality rate The decrease of 12%to 18%respectively. It may also have effects on liver cancer and esophageal cancer, and the next 4 years decreased by 22%to 15%respectively. Selenium also has certain prevention and auxiliary treatment effects on malignant lymphoma and oral cancer. China Scholars reported that the selenium supplementation of oral cancer patients can reduce the recurrence rate after surgery. Before the surgery, the selenium oral tumor has a different degree of reduction trend. Most patients with oral tumors grow slowly and stagnation. Selenium can reduce the side reaction of chemotherapy drugs and increase drugs to increase drugs. Tolerance. Selenium can also reduce the renal toxicity of cisplatin without affecting its anti -cancer activity. Clinical research of Chinese scholars also shows that selenium selenium kara gums and selenium additional liquids can prevent and reduce cisplatin renal toxicity. It can reduce blood and urine β2-micropaline by more than 50%, and can reduce the degree of white blood cells caused by chemotherapy and the amount of blood transfusion caused by it and the amount of GM-CSF. There are many reports of mechanism research, but in general, the mechanism of anti -cancer and anti -cancer is mainly the following: ① reduce the abdominability of carcinogenic factors ② selectively inhibit cancer cells. The level of selenium can significantly affect cancer Expression of genes and anticancer genes. ③ Protect the body's genetic material. ④ regulate the activity of glutathione peroxidase, glutathione phospholipid hydrogen peroxidase 3 (PHGPX), prevent lipid peroxidation, protect biofilm Not damaged and prevent mutation. ⑤ regulate the body's immune system and enhance the anti -cancer ability of the human immune system. ⑥ Increase the increase in CGMP in the tumor cells, inhibit the synthesis of DNA, RNA and protein. The diameter is controlled within 50 nanometers, which solves the two major problems of selenium absorption and utilization and safety, and creates a milestone for human selenium!